Critical Care Division

Indications :

• Complicated UTI

• Septicemia

• Skin & Soft tissue infections

• Intra-abdominal infections

• Lower respiratory tract infections

Dosage :

Adult Dose : 4.0 to 6.0 mg/kg/day as TID / BID

Paediatric Dose : 6.0 to 7.5 mg/kg/day.

Renally Impaired Patients : The initial dose is the same as that recommended for patients with normal renal function.

Packing :

Indications :

• Intra-abdominal infections.

• Urinary Tract Infections.

• Septicemia.

• Lower Respiratory Tract Infections

• Skin and soft tissue Infections.

• Bone and joint Infections.

Dosage :

Adult dose : 500 mg to 2g every 8 or 12 hrs.

Maximum Adult dose : 8g/day.

Paediatric dose : 30–90 mg/kg every 6 – 8 hrs.

Maximum Paediatric dose : 120 mg/ kg/day.

Renally Impaired Patients : After an initial loading dose of 1 to 2 grams, the dose should be halved in patients with estimated creatinine clearance between 10 and 30 mL/mi

Packing : 

Indications :

• Appendicitis and Peritonitis

• Uncomplicated and complicated skin and soft tissue infections

• Pelvic inflammatory diseases

• Community acquired pneumonia

• Nosocomial pneumonia due to S. aureus

Dosage :

Children >12 years and Adults :

Nosocomial pneumonia:
I.V. : 4.5 g every 6 hours for 7-14 days.

Severe infections :
I.V. : 4.5g every 8 hours or 3/0.375 g every 6 hours for 7-10 days.

Moderate infections :
I.M. : 2.25g every 6-8 hours; treatment should be continued for 7-10 days depending on severity of disease.

Paediatric : 112.50mg/kg TID (age 9 months or older).

90mg/kg TID (age 2months - 9months).

Really Impaired Patients :

Packing :

Amphotericin B Lipid Complex Injection 10 mg

Indications :

• Empirical therapy for presumed fungal infections.

• Treatment for systemic fungal infections.

• Cryptococcal meningitis in HIV.

• In patients where renal  impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate.

• Treatment of Visceral leishmaniasis.

Dosage : The recommended initial dose of Amphotin-Lip for each indication for adult and pediatric patients is as follows :

Doses recommended for visceral leishmaniasis are presented below:

Dosage Adjustment

Renal Impairment : Not necessary with renal impairment if decreased renal function is due to amphotericin B the daily dose can be adjusted.
Hepatic Impairment : Administer with caution.

Indications :

• Empirical therapy for presumed fungal infections

• Treatment for confirmed fungal infections

• Treatment of patients with Aspergillus spp., Candida spp. and/or Cryptococcus spp. infections refractory to amphotericin B deoxycholate

• In patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate

• Treatment of Visceral leishmaniasis

 

Dosage

The recommended initial dose of Amphotin-Lip for each indication for adult and pediatric patients is as follows :

 

Doses recommended for visceral leishmaniasis are presented below:

 

 

Dosage Adjustment

Renal Impairment : Not necessary with renal impairment if decreased renal function is due to amphotericin B the daily dose can be adjusted.
Hepatic Impairment : Administer with caution.

Indications :

 

• Empirical therapy for presumed fungal infections

• Treatment for confirmed fungal infections

• Treatment of patients with Aspergillus spp., Candida spp. and/or Cryptococcus spp. infections refractory to amphotericin B deoxycholate

• In patients where renal impairmentor unacceptable toxicity precludes the use of amphotericin B deoxycholate

• Treatment of Visceral leishmaniasis

 

Dosage 

 

The recommended initial dose of Amphotin-Lip for each indication for adult and pediatric patients is as follows :

 

Doses recommended for visceral leishmaniasis are presented below:

 

 

Dosage Adjustment

Renal Impairment : Not necessary with renal impairment if decreased renal function is due to amphotericin B the daily dose can be adjusted.
Hepatic Impairment : Administer with caution.

Cefuroxime Axetil Tablets USP 250 mg

Indications :

• Pharyngitis / Tonsilitis
• Acute Bacterial Otitis Media
• Acute Bacterial Maxillary Sinusitis
• Acute Bacterial Exacerdation of Chronic Bronchitis & Secondary Bacterial Infection of Acute Bronchitis
• Uncomplicated Urinary Tract Infections
• Uncomplicated Skin & Soft Tissue Infections
• Bone & Joint Infections due to S.aureus
• Uncomplicated gonorrhea
• Early Lyme Disease

 

Dosage

 

Oral : 250 mg to 500 mg BID for 10 days.
Uncomplicated Gonorrhea : 1gm OD
Paediatric : 30 - 100mg/kg/day BID / QID.

Renally Impaired Patients :

Indications :

• Upper Respiratory Tract Infections

• Urinary Tract Infections

• Skin & Soft Tissue Infections

• Bone & Joint Infections due to S.aureus

Dosage :

Adult :

Parenteral : 750 mg to 1.5 g every 8 hours for 5 to 10 days.

Oral : 250 mg to 500 mg BID for 10 days.

Paediatric : 30 - 100mg/kg/day BID / QID.

Renally Impaired Patients :

(Cefuroxime Sodium For Injection USP 750 mg)

Indications :

• Lower Respiratory Tract Infections
• Septicemia
• Perioperative Prophylaxis
• Gonorrhea
• Meningitis

• Urinary Tract Infections

• Skin & Soft Tissue Infections

• Bone & Joint Infections due to S.aureus

Dosage :

Adult :

Parenteral : 750 mg to 1.5 g every 8 hours for 5 to 10 days.

Maximum Dose : 3gm every 8 hrs.

Paediatric : 50 - 100mg/kg/day TID / QID.

Renally Impaired Patients :

Indications :

• Upper Respiratory Tract Infections

• Urinary Tract Infections

• Skin & Soft Tissue Infections

• Bone & Joint Infections due to S.aureus

Dosage :

Adult :

Parenteral : 750 mg to 1.5 g every 8 hours for 5 to 10 days.

Oral : 250 mg to 500 mg BID for 10 days.

Paediatric : 30 - 100mg/kg/day BID / QID.

Renally Impaired Patients :

(Amoxicillin And Clavulanate Potassium Injection USP 1.2 g)

Indications :

• Lower Respiratory Tract Infections

• Upper Respiratory Tract Infections

• Skin and Soft Tissue Infections

• Genito Urinary Tract Infections

Dosage :

Intravenous Dosage : 2 Vial 0.6 g or 1 Vial of 1.2 g 6-8 hourly.

Pediatric : 30 mg /kg in divided dose.

Renally Impaired Patients :

Clavox (Amoxicillin And Clavulanate Potassium Injection USP 0.6 g)

Indications :

• Lower Respiratory Tract Infections

• Upper Respiratory Tract Infections

• Skin and Soft Tissue Infections

• Urinary Tract Infections

Dosage :

Intravenous Dosage : 2 Vial 0.6 g or 1 Vial of 1.2 g 6-8 hourly.

Pediatric : 30 mg /kg in divided dose.

Renally Impaired Patients :

(Clindamycin 600mg Amp.)

Indications :

• Serious infection caused by susceptible strains of streptococci, pneumocci & staphylococci.
• Lower respiratory infections including bronchitis, pneumonia, emphyema and lung abscess.
• Bone and joint infections including staphylococcal osteomyelitis and septic arthritis.
• Pelvic infections including endometritis, cellulitis, vaginal cuff infection, tubo-ovarian abscesses, salpingitis and pelvic inflammatory disease .
• Intra-abdominal infections including peritonitis, liver abscess , abdominal
  abscess & biliary tract infection .
• Septicemia and endocarditis.
• Skin and soft tissue infections including acne, furuncles, cellulitis, impetigo, abscesses, and wound infections.

 

Dosage : The recommended dosages are :


Clinzucia Injection :

Adults :

Serious infections : 600-1200mg/day in 2, 3 or 4 equal doses either IM or IV administration.

More Severe Infection : 1200 -2700 mg/day in 2,3 or 4 equal doses (IM or IV)

Neonates : 15 to 20mg/kg/day in 3 to 4 equal doses.

Pediatric Patients : 20 to 40mg/kg/day in 3 or 4 equal doses either IM or IV administration.

(Clindamycin 150mg Capsules)

Indications :

• Serious infection caused by susceptible strains of streptococci, pneumocci & staphylococci.
• Lower respiratory infections including bronchitis, pneumonia, emphyema and lung abscess.
• Bone and joint infections including staphylococcal osteomyelitis and septic arthritis.
• Pelvic infections including endometritis, cellulitis, vaginal cuff infection, tubo-ovarian abscesses, salpingitis and pelvic inflammatory disease .
• Intra-abdominal infections including peritonitis, liver abscess, abdominal abscess & biliary tract infection .
• Septicemia and endocarditis.
• Skin and soft tissue infections including acne, furuncles, cellulitis, impetigo, abscesses, and wound infections.

Dosage : The recommended dosages are :

Clinzucia Capsules

Adults

Severe infections : 150 to 300mg every 6 hours.

More severe infections: 300mg to 450 mg every 6 hours.

Pediatrics :

Severe infections : 8 to 16mg/kg/day divided into three or four equal doses. 

More severe : 16 to 20mg/kg/day divided into three or four equal doses.

Indications :

• Upper respiratory infections including tonsillitis, pharyngitis, sinusitis, otitis media and scarlet fever.

• Lower respiratory infections including bronchitis, pneumonia, emphyema and lung abscess.

• Bone and joint infections including staphylococcal osteomyelitis and septic arthritis.

• Pelvic infections including endometritis, cellulitis, vaginal cuff infection, tubo-ovarian abscesses, salpingitis and pelvic inflammatory disease .

• Intra-abdominal infections including peritonitis, liver abscess , abdominal abscess & biliary tract infection .

• Septicemia and endocarditis.

• Dental infections such as periodental abscess and periodonitis.

• As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciparum infection.

• Skin and soft tissue infections including acne, furuncles, cellulitis, impetigo, abscesses, and wound infections.

Dosage : The recommended dosages are :
Clinzucia Capsules.

Adults :

Moderate infections : 50 to 300mg every 6 hours.

More severe infections: 300mg to 450 mg every 6 hours.

Paediatrics :

Moderate infections : 8 to 12mg/kg/day divided into three or four equal doses.

More severe : 16 to 20mg/kg/day divided into three or four equal infections doses.

Clinzucia Injection

Adults :

Serious infections : 600-1200mg/day in 2, 3 or 4 equal doses either IM or IV administration.

Neonates : 15 to 20mg/kg/day in 3 to 4 equal doses.

Pediatric Patients : 20 to 40mg/kg/day in 3 or 4 equal doses either IM or IV administration.

Indications :

• Upper respiratory infections including tonsillitis, pharyngitis, sinusitis, otitis media and scarlet fever.

• Lower respiratory infections including bronchitis, pneumonia, emphyema and lung abscess.

• Bone and joint infections including staphylococcal osteomyelitis and septic arthritis.

• Pelvic infections including endometritis, cellulitis, vaginal cuff infection, tubo-ovarian abscesses, salpingitis and pelvic inflammatory disease .

• Intra-abdominal infections including peritonitis, liver abscess , abdominal abscess & biliary tract infection .

• Septicemia and endocarditis.

• Dental infections such as periodental abscess and periodonitis.

• As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciparum infection.

• Skin and soft tissue infections including acne, furuncles, cellulitis, impetigo, abscesses, and wound infections.

Dosage : The recommended dosages are :

Clinzucia Capsules

Adults :

Moderate infections : 50 to 300mg every 6 hours.

More severe infections: 300mg to 450 mg every 6 hours.

Paediatrics :

Moderate infections : 8 to 12mg/kg/day divided into three or four equal doses.

More severe : 16 to 20mg/kg/day divided into three or four equal infections doses.

Clinzucia Injection

Adults :

Serious infections : 600-1200mg/day in 2, 3 or 4 equal doses either IM or IV administration.

Neonates : 15 to 20mg/kg/day in 3 to 4 equal doses.

Pediatric Patients : 20 to 40mg/kg/day in 3 or 4 equal doses either IM or IV administration.

(Tigecycline 50mg Vial)

Indications :

• Complicated Skin & Skin Structure infections.

• Complicated Intra-Abdominal infections.

• Community – Acquired Bacterial Pneumonia.

Dosage : Initial dose of 100mg, followed by 50mg every 12 hrs. IV should be administered approx. 30-60 mins. every 12 hrs.

Renal Insufficiency : No dosage adjustment required.

Hepatic Insufficiency : No dosages adjustment required in mild & moderate hepatic impairment (Child Pugh A and Child Pugh B). In patient with severe hepatic impairment (Child Pugh C) should be 100 mg followed by a reduced maintenance dose of 25 mg every 12 hours.

(Cefepime 1g Vial)

Indications :

• Pneumonia (S. pneumoniae, P. aeruginosa, K. pneumoniae, or Enterobacter species).

• Empiric Therapy for Febrile Neutropenia.

• Uncomplicated & Complicated Urinary Tract Infections including pyelonephritis.

• Uncomplicated Skin and Skin Structure Infections (S. aureus and S. pyogenes).

• Intra-abdominal Infections (E. coli, viridans group streptococci, P. aeruginosa, K. pneumoniae, Enterobacter species, or B. fragilis).

Dosage : Initial dose of 100mg, followed by 50mg every 12 hrs.

Adults: IV: 1-2g every 8-12 hrs; IM: 0.5-1g every 12 hrs

Children: IM, IV: 50 mg/kg/dose every 8-12 hours (not to exceed maximum adult dosing)

Renal: Dosages adjustment required according to CrCl.

Indications and Dosage :

(Ceftazidime For Injection USP 1g)

Indications :

• Skin & Soft tissue infections.
• Gynaecological infections.
• Intraabdominal infections.
• Lower respiratory tract infections (including pneumonia)
• Urinary Tract Infections

• Bacterial septicemia

• Bone & Joint infections
  Concomitant Therapy with other antibiotics in severe & life threatening infections.

• CNS infections

Dosage :

Adult Dose : 1g IV or IM daily in divided dose every 8 or 12 hrs.

Paediatric Dose : 30 to 50 mg/kg daily every 8 hours.

Renally Impaired Patients :

Indications :

• Infections primarily caused by Pseudomonas sp.

• Lower respiratory tract infections (including pneumonia)

• Urinary Tract Infections

• Bacterial septicemia

• As a prophylactic agent in the surgical infections

• Bone & Joint infections

• Febrile Neutropenia

• CNS infections

Dosage :

Adult Dose : 1 to 6 g daily in divided dose every 8 or 12 hrs.

Paediatric Dose : 30 to 100 mg/kg daily in 2 or 3 divided doses.

Renally Impaired Patients :

(L-Ornithine-L-Aspartate Granules 3g)

Indications :

• Encephalopathy

• Acute Liver Failure

• Hyperammonemia due to liver cirrhosis, hepatitis, Fatty liver

• Jaundice

Dosage :

Sachets :1-2 Sachet (Dissolve in a glass of water) 3 Times a day

Renally Impaired Patients : Not known, administer with caution. 

Packing : 10 Sachets of 5g

(L-Ornithine-L-Aspartate Infusion 5 g/10 ml)

Indications :

• Encephalopathy
• Acute Liver Failure
• Hyperammonemia due to liver cirrhosis, hepatitis, Fatty liver
• Jaundice

Dosage : 

Injection

Adult : 4 amp. x 4 days or 8 amp. x 4 days and then 4 amp. x 3 days.

Maximum infusion rate : 5g / hr.

Renally Impaired Patients : Not known, administer with caution.

Packing : 5 Ampoules of 10 ml

(L-Ornithine-L-Aspartate + Pancreatin Tablets 150 mg)

Indications :

• Encephalopathy

• Acute Liver Failure

• Hyperammonemia due to liver cirrhosis, hepatitis, Fatty liver

• Jaundice

Dosage :

Tablets : 1-2 tablets 3 times a day for 3 months. 

Renally Impaired Patients : Not known, administer with caution.

 Packing : 10 Strips of 10 Tablets

(Cefoperazone Sodium 2gm)

Indications :

• Peritonitis.

• Bacterial septicaemia.

• Skin and Soft Tissue Infections.

• Pelvic Inflammatory disease.

Dosage :

Adult : 2-4 gm / day in 2 equally divided doses.
Paediatric : 50-200 mg/ kg/ day in 2 equally divided doses.

Renally Impaired Patients : No dosage adjustment with normal hepatic function. If hepatic disease and severe renal failure (CrCl<10) than max. dose ranges from 1-2g/day.

Packing : 1 Vial of 2gm

(Cefoperazone Sodium 1gm)

Indications :

• Peritonitis.

• Bacterial septicaemia.

• Skin and Soft Tissue Infections.

• Pelvic Inflammatory disease.

Dosage :

Adult : 2-4 gm / day in 2 equally divided doses.
Paediatric : 50-200 mg/ kg/ day in 2 equally divided doses.

Renally Impaired Patients : No dosage adjustment with normal hepatic function. If hepatic disease and severe renal failure (CrCl<10) than max. dose ranges from 1-2g/day.

Packing : 1 Vial of 1gm

(Cefoperazone And Sulbactam 2gm)

Indications :

• Bacterial septicaemia
• Respiratory Tract Infection
• Urinary Tract Infection
• Peritonitis
• Skin and Soft Tissue Infections
• Pelvic Inflammatory disease.

Dosage :

Adult :

2-4 gm / day in 2 equally divided doses.

Paediatric :

50-200 mg/ kg/ day in 2 equally divided doses.

Renally Impaired Patients :

No dosage adjustment required.

 Packing : 1 Vial of 2g

Indications :

• Bacterial septicaemia.

• Peritonitis.

• Skin and Soft Tissue Infections.

• Pelvic Inflammatory disease.

Dosage :

Adult :

2-4 gm / day in 2 equally divided doses.

Paediatric :

50-200 mg/ kg/ day in 2 equally divided doses.

Renally Impaired Patients :

No dosage adjustment required.

Packing : 1 Vial of 1g

(Cefoperazone And Sulbactam For Injection 3gm)

Indications :

• Respiratory Tract Infections

• Peritonitis and other intra-abdominal infections

• Bacterial septicaemia

• Skin and Soft tissue infections

• Prophylaxis in Pre/Post Operative Infections

Dosage :

Adult : 1.5-3g every 12 hours in equally divided doses.

Pediatric : 30-60 mg/kg/day every 6 to 12 hours in equally divided doses.

Renally Impaired Patients : Dosage adjustment required.

Packing : 10 Vials of 3g

(Cefoperazone And Sulbactam For Injection 1.5g)

Indications :

• Respiratory Tract Infections

• Peritonitis and other intra-abdominal infections

• Bacterial septicaemia

• Skin and Soft tissue infections

• Prophylaxis in Pre/Post Operative Infections

Dosage :

Adult : 1.5-3g every 12 hours in equally divided doses.

Pediatric : 30-60 mg/kg/day every 6 to 12 hours in equally divided doses.

Renally Impaired Patients : Dosage adjustment required.

Packing : 10 Vials of 1.5g

(Lactulose 200mg Bottles)

Indications :

• Constipation (Surgery, Pregnancy).

• Portal Systemic Encephalopathy.

Dosage :

Constipation

Adult : 15-30 ml may be increased to 60ml daily.

Paediatric : 5-15 ml 1-2 times a day.

Dose in Portal Systemic Encephalopathy : Start with 30-45 ml 3-4 times daily.

Renally Impaired Patients : No dosage adjustment required.

Packing : 1 Bottle of 200 ml

Indications :

• Constipation (Surgery, Pregnancy).

• Hepatic Encephalopathy.

• Salmonellosis.

• Renal Insufficiency.

Dosage :

Adult : 15-30 ml3-4 times a day.
Paediatric : 5-15 ml1-2 times a day.

Dose in Hepatic Encephalopathy : Start with 30-40 ml over every 1 hour.

Renally Impaired Patients : No dosage adjustment required.

 Packing : 1 Bottle of 100 ml.

(Meropenem For Injection USP 1g)

Indications :

• Intra abdominal infections.
• Bacterial Meningitis.
• Complicated SSTI
• Nosocomial pneumonia.

Dosage :

Adult Dose : 500mg - 1g IV TID.

Pediatric Dose : 10-20mg/kg IV every 8 hrs.

Dosage Adjustment :

Renal Impairment : Required.

Hepatic Impairment : Not necessary.

Packing : 10 Vials of 1g

Indications :

• Intra abdominal infections.

• Bacterial Meningitis.

• Nosocomial pneumonia.

• Septicaemia.

• Empiric Antibiotic therapy in Febrile Neutropenia.

Dosage :
Adult Dose : 500mg - 1g IV TID.

Pediatric Dose : 10-20mg/kg IV every 8 hrs.

Dosage Adjustment :
Renal Impairment : Required.
Hepatic Impairment : Not necessary.

Packing : 10 Vials of 500 mg

(Acetylcysteine 600mg Tablets)

Indications :

Adjuvant therapy with abnormal and viscous mucus secretions in :

• Chronic Bronchopulmonary Diseases like: Chronic emphysema, Emphysema with Bronchitis, Chronic asthmatic Bronchitis, Tuberculosis, Bronchiectasis, Primary Amyloidosis of Lungs.

• Acute Bronchopulmonary Diseases like: Pneumonia, Bronchitis, Tracheo-bronchitis Pulmonary complications of Cystic fibrosis & those associated with surgery.

• Post tracheostomy care.

• During Anaesthesia.

• Pos traumatic chest conditions.

• Atelactasis due to mucus obstruction.

• Overdosage of acetaminophen.

Dosage :

Usual adult and adolescent dose :

As Mucolytic :

Adult Dose : 600mg OD

Pediatric Dose : 200mg OD

Prevention of Acute Renal failure associated with radiographic contrast media : 600mg BID.

Renally Impaired Patients : Caution is necessary.

Packing : 10 Strips of 4 Tablets.

(Acetylcysteine 20% Solution USP 5ml)

Indications :

Adjuvant therapy with abnormal and viscous mucus secretions in :

• Chronic Bronchopulmonary Diseases like: Chronic emphysema, Emphysema with Bronchitis, Chronic asthmatic Bronchitis, Tuberculosis, Bronchiectasis, Primary Amyloidosis of Lungs.

• Acute Bronchopulmonary Diseases like: Pneumonia, Bronchitis, Tracheo-bronchitis Pulmonary complications of Cystic fibrosis & those associated with surgery.

• Post tracheostomy care.

• During Anaesthesia.

• Pos traumatic chest conditions.

• Atelactasis due to mucus obstruction.

• Chemoprevention and treatment.
  
  Overdosage of acetaminophen.

  Dosage :

Usual adult and adolescent dose :

As Mucolytic : Administration can be by nebulization of 1 to 10 ml of the 20% solution or 2 to 20 ml of the 10% solution may be given every 2 to 6 hours. When used by direct instillation, 1 to 2 ml of 20% solution may be given as often as every hour.

As antidote for acetaminophen overdose : Oral, 140 mg per kg of body weight initially, followed by 70 mg per kg of body weight every four hours for 17 additional doses Oral administration requires dilution of the 20% solution with diet cola, or other diet soft drinks, to a final concentration of 5%.

Cancer : 500-600mg TID

Cancer Prevention : 600-100mg OD

Renally Impaired Patients : Caution is necessary.

Packing : 10 Packs of 5 Ampoules of 5 ml

(Acetylcysteine 20% Solution USP 2 ml)

Indications :

Adjuvant therapy with abnormal and viscous mucus secretions in :

• Chronic Bronchopulmonary Diseases like: Chronic emphysema, Emphysema with Bronchitis, Chronic asthmatic Bronchitis, Tuberculosis, Bronchiectasis, Primary Amyloidosis of Lungs.

• Acute Bronchopulmonary Diseases like: Pneumonia, Bronchitis, Tracheo-bronchitis Pulmonary complications of Cystic fibrosis & those associated with surgery.

• Post tracheostomy care.

• During Anaesthesia.

• Pos traumatic chest conditions.

• Atelactasis due to mucus obstruction.

• Chemoprevention and treatment.

• Overdosage of acetaminophen.

Dosage :
Usual adult and adolescent dose :

As Mucolytic : Administration can be by nebulization of 1 to 10 mlof the 20% solution or 2 to 20 mlof the 10% solution may be given every 2 to 6 hours. When used by direct instillation, 1 to 2 ml of a 10% to 20% solution may be given as often as every hour.

As antidote for acetaminophen overdose : Oral, 140 mg per kg of body weight initially, followed by 70 mg per kg of body weight every four hours for 17 additional doses Oral administration requires dilution of the 20% solution with diet cola, or other diet soft drinks, to a final concentration of 5%.

Cancer : 500-600mg TID

Cancer Prevention : 600-100mg OD

Renally Impaired Patients : Caution is necessary.

Packing : 10 Packs of 2 Ampoules of 2 ml.

(Sterile Noradrenalin Concentrate BP 2mg/ml)

Indications :

• Restore blood pressure in acute hypotensive states.

• Cardiac Arrest

Dosage :

Adult Dose : The usual initial dose is 8-12mcg/min.

Average maintenance dose is 2mcg-4mcg/min.

Pediatric Dose : The usual dose is 1-2 mcg/kg/min. or 2 mcg/m²/min.

Renally Impaired Patients : Not known, administer with caution.

Packing : 10 Packs of 2 Ampoules of 2 ml.

Indications :

Neurological Conditions
Multiple Sclerosis, Spinal Cord Injury, Cerebral Injury
Nephrological Conditions
Glomerular Nephritis, Lupus Nephritis
Organ Transplant
Rheumatic Conditions
Acute Gouty Arthritis, Acute Rheumatic Carditis, Psoriatic Arthritis, Rheumatoid Arthritis
Acute Respiratory Distress Syndrome (ARDS)

Dosage :

May be administered by IV or IM injection or by IV infusion. The preferred method for initial
emergency is IV injection.

Usual Doses : 30mg/kg administered IV over atleast 30 minutes. This dose may be repeated every 4-6 hour for 48 hours.

Initial Doses : 10-40mg IV over a period of several minutes. The larger doses may be required for short term management of severe, acute conditions.

In Multiple Sclerosis : 200mg for a week followed by 80mg every other day for one month.

In Renal Transplantation :
For induction of Immunosuppression : Start with 80-160mg OD for three days followed by oral therapy.
In treatment of acute rejection : 500 mg upon diagnosis, followed by 500 mg OD for two days.

Acute Spinal Cord Injury : 30 mg/kg bolus followed by 5.4 mg/kg  bolus for 24-48 hours.

Prevention of ARDS and Fat Embolism syndrome : 30 mg/kg body weight can be repeated after 6 hours.
Packing : 1 Vial of 1g

SOL - U- PRED (Methylprednisolone Sodium Succinate 500MG Vial)

Indications :

Neurological Conditions
Multiple Sclerosis, Spinal Cord Injury, Cerebral Injury
Nephrological Conditions
Glomerular Nephritis, Lupus Nephritis
Organ Transplant
Rheumatic Conditions
Acute Gouty Arthritis, Acute Rheumatic Carditis, Psoriatic Arthritis, Rheumatoid Arthritis
Acute Respiratory Distress Syndrome (ARDS)

Dosage :

May be administered by IV or IM injection or by IV infusion. The preferred method for initial
emergency is IV injection.

Usual Doses : 30mg/kg administered IV over atleast 30 minutes. This dose may be repeated every 4-6 hour for 48 hours.

Initial Doses : 10-40mg IV over a period of several minutes. The larger doses may be required for short term management of severe, acute conditions.

In Multiple Sclerosis : 200mg for a week followed by 80mg every other day for one month.

In Renal Transplantation :
For induction of Immunosuppression : Start with 80-160mg OD for three days followed by oral therapy.
In treatment of acute rejection : 500 mg upon diagnosis, followed by 500 mg OD for two days.

Acute Spinal Cord Injury : 30 mg/kg bolus followed by 5.4 mg/kg  bolus for 24-48 hours.

Prevention of ARDS and Fat Embolism syndrome : 30 mg/kg body weight can be repeated after 6 hours.
Packing : 1 Vial of 500mg

(Azithromycin 500mg Injection)

Indications : 

• Community – acquired pneumonia

• Pelvic Inflammatory Disease

Dosage :

Adult :

Packing : 1 Vial of 500mg

(Azithromycin 500mg Tablets)

Indications :

Adults:

• Community – acquired pneumonia

• Acute Exacerbation of Chronic Obstructive Pulmonary Diseas

• Pharyngitis/Tonsillitis

• Uncomplicated Skin Infection

• Urethritis, Cervicitis, Pelvic Inflammatory Disease and Genital Ulcers

Children:

• Acute otitis media

• Community-acquired pneumonia

• Pharyngitis/ tonsillitis

Dosage :

Adult :

Packing : 1 Strip of 3 Tabs

(Azithromycin 250mg Tablets)

Indications :

Adults:

• Community – acquired pneumonia

• Acute Exacerbation of Chronic Obstructive Pulmonary Diseas

• Pharyngitis / Tonsillitis

• Uncomplicated Skin Infection

• Urethritis, Cervicitis, Pelvic Inflammatory Disease and Genital Ulcers

• Cystic Fibrosis

 

Children:

• Acute otitis media

• Community-acquired pneumonia

• Pharyngitis/ tonsillitis

Dosage :
Adult :

Packing : 1 Strip of 6 Tabs.

(Teicoplanin For Injection 400mg Lyophilized )

Indications :

• Osteomyelitis

• Endocarditis
• UTI
• Peritonitis Associated with chronic
 ambulatory Peritoneal dialysis (CAPD)
• Respiratory Infections

Dosage :

Adult Dose :
Acute or chronic osteomyelitis : 400mg IV every 12 hr for 3 doses then 400 mg once daily as maintenance dosage.

Pediatric Patients:
(Children aged 2 months - 16 years) For severe infection and infection in neutropenic patients : 10 mg /kg every 12 hr for 3 dosages and then 10 mg / kg as a single dose once daily.

For moderate infections : 10 mg / kg IV every 12 hr for first three doses thereafter 6 mg / kg as IV or IM as single dose once daily.

Renally Impaired Patients : For patients with impaired renal function, reduction of dosage is not required until the fourth day of treatment.

Packing : 5 Vials of 400 mg

Indications :

• Serious infections due to Staphylococci or Streptococci

• Osteomyelitis

• Septic arthritis

• Non cardiac Bacteraemia, Septicemia

• Febrile Neutropenia

Dosage :

Adult dose :
Septicaemia/Bacteraemia/ Acute or chronic osteomyelitis : 400mg IV every 12 hr for 3 doses then 400 mg once daily as maintenance dosage.

Septic Arthritis : 800mg IV every 12 hr for 3 dosages then 800mg once daily as maintenance dosage.

Pediatric patients :
(Children aged 2 months - 16 years) For severe infection and infection in neutropenic patients : 10 mg /kg every 12 hr for 3 dosages and then 10 mg / kg as a single dose once daily.

For moderate infections : 10 mg / kg IV every 12 hr for first three doses thereafter 6 mg / kg as IV or IM as single dose once daily.

Renally Impaired Patients : For patients with impaired renal function, reduction of dosage is not required until the fourth day of treatment.

Packing : 5 Vials of 200 mg

(Ticarcillin and clavulanic acid for injection USP 3.1 g)

Indications :

• Septicemia (including bacteremia)

• Lower Respiratory Tract Infections

• Bone and Joint Infections

• Skin and Skin Structure Infections

• Urinary Tract Infections

• Gynecological Infections

• Intra-abdominal Infections (Peritonitis 
• Mixed Infections

Dosage :

Adults 60 kg or greater : 3.1 g every 4 to 6 hours.

Adults Less than 60kg : 200 to 300 mg/kg/day (based on ticarcillin content) every 4 to 6 hours.

Infants & Children :
Non U.T.I.
Severe : 50mg/kg every 4 hours.

Mild-moderate : 50mg/kg every 6 hours.

U.T.I.
Complicated : 50mg/kg every 4 hours.

Uncomplicated : 50mg/kg every 6 hours.

Renally Impaired Patients : Dosage adjustments required.

Packing : 10 Vials of 3.1 g

(Tobramycin Injection USP 80 mg)

Indications :

• Lower Respiratory Tract Infections

• Complicated and recurrent UTIs

• Intra abdominal infections

• Septicemia

• Serious CNS infections
• Skin, bone & skin structure infections.

• Prophylaxis in Surgery

Dosage :

 Adult dose: 3-5 mg/kg daily in 3 or 4 divided doses.

Paediatric dose : 6-7.5 mg/kg in 3 or 4 divided doses.

Renally Impaired Patients:

 

High-dose (once daily) therapy:

Packing : 25 Vials of 80 mg/2 ml

Indications :

• Chronic Renal Failure

• Chronic Glomerulonephritis

• Chronic Pyelonephritis

• Polycystic Kidney Disease

• Analgesic Nephropathy

• Nephrosclerosis

Dosage :

2 tablets T.D.S.

The tablets should be swallowed as whole and taken with 3-5 meals evenly distributed over the day.

Packing : 1 Strip of 10 Tabs

(Calcitonin Salmon Nasal Solution USP 3.7 ml 30 MD)

Indications :

Post Menopausal Osteoporosis

 Dosage :

One spray (200 IU) per day administered intranasally, alternating nostrils daily.

Renally Impaired Patients : No dosage adjustment required.

Packing : 10 Spray Bottles of 3.7 ml Solution.

(Calcitonin Salmon Injection USP 100 IU)

Indications :

• Paget's Disease (Osteitis deformans)

• Hypercalcemia

• Post Menopausal Osteoporosis

Dosage :

Osteoporosis/Post Menopausal Osteoprosis : 100 IU once a day on alternate days.

Paget's Disease :
Initial Dose : 100 units per day

Maintenance Dose : 50 IU once a day on alternate days.

Hypercalcemia : 4 IU/kg body wt I.V. every 12 hrs.

Maximum Dose : 8 IU/kg every 6 hrs.

Renally Impaired Patients : No dosage adjustment required.

Packing : 5 Ampoules of 100 IU/1 ml

Indications :

• Paget's Disease (Osteitis deformans)

• Hypercalcemia 2

• Post Menopausal Osteoporosis

• Metastatic Bone Pain

• Reflex Sympathetic Dystrophy

• Bone pain associated with osteolysis & osteopenia

• Adjuvant therapy for acute pancreatitis

Dosage :

 Osteoporosis/Post Menopausal Osteoprosis :
100 IU once a day on alternate days.

Paget's Disease :
50 IU once a day on alternate days.

Hypercalcemia :
4-8 IU/kg body wt I.V. every 12 hrs.

Renally Impaired Patients : No dosage adjustment required.

Packing : 5 Ampoules of 50 IU/1 ml

(Polymyxin B For Injection USP 500000 Units)

Indications :

Pseudomonal infections : Infections of urinary tract, meninges & bloodstream infections caused due to P. aeruginosa.

Serious infections from H. influenzae, E. coli, Enterobacter aerogenes, Klebsiella pneumoniae.

Dosage :

IV :

Adult & Children : 25,000 units/kg/day in divided doses every 12 hours.

Infants : Upto 25,000 units/kg/day (Intrathecal).

IM :

Adult & Children : 25,000–30,000 units/kg daily administered in divided doses at 4 to 6 hour intervals.

Infants : Up to 40,000 units/kg daily.

Intrathecal Dose incase of P. aeruginosa meningitis.

Packing : 10 Vials of 500000 Units

Indications :

• Prevention of Meningococcal Meningitis

• Respiratory tract infections

• Septicemia

• Surgical Prophylaxis

• Gonorrhea

Dosage :

Adult Dose: 1 to 2 g once a day.

Maximum Dose : 4g / day.

Paediatric Dose : 50 to 75 mg/kg in divided doses.

Maximum Dose : 2g / day.

Renally Impaired Patients : Dosage regimen should be adjusted in patients with marked decrease in renal function (creatinine clearance of < 30ml/min) and to compensate for reduced clearance less than 15ml/min patient should receive a maximum of 500mg of sulbactam every 12 hours (maximum dose 1 gram of sulbactam).

Packing : 10 Vials of 1.5 g

(Aciclovir Sodium For Intravenous Infusion BP 250mg)

Indications :

Mucosal and cutaneous HSV infections in immuno-compromised patients.

Varicella – Zoster infections (shingles) in immuno-compromised patients.

Herpes Simplex encephalitis.

Initial Episodes of herpes genitalis

Dosage :

Adult Dose : 5-10 mg/kg infused at a constant rate over 1 hr every 8 hr for 7-10 days.

Paediatric Dose : 250- 500 mg / m² infused at a constant rate over 1 hr every 8 hr for 7-10 days.

Renally Impaired Patients :

 

Packing : 5 Vials of 250 mg

(Vancomycin Hydrochloride For Injection USP 500 mg)

Indications :

• In treatment of Endocarditis due to staphylococcus & streptococcus.
  

• Pseudomenbranous colitis.

• Staphylococcal enterocolitis.

Dosage :

Endocarditis : 2gm IV divided as 500mg every 6 hrs.

Pseudomenbranous colitis / Staphylococcal enterocolitis : 500mg-2gm daily given in 3 or 4 divided dose.

Staphylococcal Infections : 2gm IV divided as 500mg every 6 hrs. or 1gm every 12 hrs.

Adult Dose : The usual adult dose is the equivalent of 500 mg of vancomycin every 6 hours or
1 g every 12 hours.

Paediatric Dose  : 10 - 15 mg/kg every 8 hours.

Renally Impaired Patients :

Packing : 10 Vials of 500 mg.

Indications :

• Respiratory Tract Infections

• Endocarditis

• Pseudomonas colitis

• Prophylaxis in Surgery / Organ Transplant

Dosage :

Adult dose : The usual adult dose is the equivalent of 500 mg of vancomycin every 6 hours or
1 g every 12 hours.

Paediatric dose : 10 - 15 mg/kg every 8 hours.

Renally Impaired Patients :

Packing : 10 Vials of 1g